IPIX Streamlines Operations and Reduce Costs

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RESTON, Va. – Nov. 18, 2005 – IPIX Corporation (NASDAQ: IPIX) today detailed actions the company is taking to further streamline its structure and reduce costs. Combined with previous operational adjustments in August 2005, the company expects these actions to reduce personnel costs, facility costs and expenses and consolidate all operations into the company's Reston, VA. headquarters. The company expects that these reductions will mitigate the company's losses.

Most of these actions will streamline IPIX's operations to more effectively address our client prospects, needs and opportunities.

"After a thorough review of the third quarter financials, we are making additional changes that while difficult will uphold our obligation to shareholders," said Clara Conti, IPIX chief executive officer and president. "After analyzing our business operations, we are confident this is the best path forward. We are absolutely committed to delivering the best performance - for our shareholders, customers and employees."

Today IPIX is reducing 15 staff positions. These changes will help to better position the company for further growth.

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About IPIX

IPIX Corporation is a premium provider of immersive imaging products for government and commercial applications. We combine experience, patented technology and strategic partnerships to deliver visual intelligence solutions worldwide. Our immersive, 360-degree imaging technology has been used to create high-resolution digital still photography and video products for surveillance, visual documentation and forensic analysis. www.ipix.com

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This press release may contain forward-looking information within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, and is subject to the safe harbors under those sections. In some cases, you can identify forward-looking statements by terminology such as "expect," "believe," "may," "will," "plans" and "anticipate," or the negative of such terms or comparable terminology. Forward-looking statements appearing herein include statements concerning operating and profitability plans and goals and restructuring efforts and are based on current expectations.

Actual results may differ materially from those projected in the forward-looking statements based upon a number of factors including: changes in the demand for our products and services; our third-party supplier's ability to deliver high quality components to us in a timely fashion; our ability to control or effect reductions in costs; uncertainty regarding our ability to continue as a going concern; our ability to raise capital and fund our operations; our ability to attract and retain highly qualified personnel; our ability to design, manufacture and deliver high quality products in a timely fashion; and, the burdens and costs of defending against potential infringement claims.

The matters discussed in this press release also involve risks and uncertainties described from time to time in documents filed with the Securities and Exchange Commission, including but not limited to Form 10-Ks, Form 10-K/As, Form 10-Qs, Form S-3s and Form 8-Ks (www.sec.gov).

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IPIX Media Contact

(202) 478-3563